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Hexa 612/18/2023 ![]() At least 25.4% (anti-PT), 97.5% (anti-FHA) and 87.0% (anti-PRN) of children were seropositive against the pertussis components. Protective immunity against the three poliovirus types and PRP was observed in at least 91.0% of children and against diphtheria and tetanus in at least 64.7% of children. Persistence of the immune response: The persistence of the immune response to a 3-dose primary and booster schedule with Infanrix Hexa was evaluated in children 4-8 years of age. In a follow-up study, approximately 2.5 to 3 years after the booster dose, 85.3% of the children were still seroprotected against hepatitis B and at least 95.7% were seroprotected against the three poliovirus types and PRP. ![]() The response to the booster dose in terms of fold increases in antibody concentrations (15- to 235-fold), indicate that preterm infants were adequately primed for all the antigens of Infanrix Hexa. One month after the booster dose at least 98.4% of subjects had seroprotective or seropositive antibody levels against each of the antigens except against PT (at least 96.8%) and hepatitis B (at least 88.7%). One month after primary vaccination at least 98.7% of subjects were seroprotected against diphtheria, tetanus and poliovirus type 1 and 2 at least 90.9% had seroprotective antibody levels against the hepatitis B, PRP and poliovirus type 3 antigens and all subjects were seropositive for antibodies against FHA and PRN while 94.9% were seropositive for anti-PT antibodies. The immunogenicity of a booster dose at 18 to 24 months of age was evaluated in approximately 200 preterm infants. Immunogenicity in preterm infants: The immunogenicity of Infanrix Hexa was evaluated across three studies including approximately 300 preterm infants (born after a gestation period of 24 to 36 weeks) following a 3-dose primary vaccination course at 2, 4 and 6 months of age. However, as the immune response to pertussis antigen following Infanrix Hexa administration is equivalent to that of Infanrix, the protective efficacy of the two vaccines is expected to be equivalent.Įfficacy in protecting against pertussis: The protective efficacy of the pertussis component of Infanrix against WHO-defined typical pertussis (≥ 21 days of paroxysmal cough) was demonstrated after 3-dose primary immunisation in the studies tabulated as follows: See Table 4. For pertussis there is no serological correlate of protection. Serological correlates of protection have been established for diphtheria, tetanus, polio, Hepatitis B and Hib. After booster vaccination (post-dose 4), at least 98.4% of children had developed seroprotective or seropositive antibody levels against each of the vaccine antigens.Īfter a complete vaccination according to a 2-dose primary and booster schedule with Infanrix Hexa, at least 97.9% of the subjects had developed seroprotective or seropositive antibody levels against each of the vaccine antigens. (See Tables 2 and 3.)Īfter a 3-dose primary vaccination schedule, at least 95.7% of infants had developed seroprotective or seropositive antibody levels against each of the vaccine antigens. The results of these clinical studies are summarised in Tables 2 and 3 as follows. The vaccine was assessed in 2-dose and 3-dose priming schedules, including the schedule for the Expand Program on Immunisation, and as a booster dose. Pharmacology: Pharmacodynamics: Immunogenicity: The immunogenicity of Infanrix Hexa has been evaluated in clinical studies from 6 weeks of age. Pharmacotherapeutic group: Bacterial and viral vaccines combined. Only five such numbers are known to exist sixty (10 × 6) and ninety (15 × 6) are the next two. Six is the first unitary perfect number, since it is the sum of its positive proper unitary divisors, without including itself. 6 is the root of the 6-aliquot tree, and is itself the aliquot sum of only one other number the square number, 25.6 is the only even perfect number that is not the sum of successive odd cubes. ![]() 6 is related to the Mersenne prime 3, since 2 1(2 2 – 1) = 6. ![]() All primes above 3 are of the form 6 n ± 1 for n ≥ 1. It is the first discrete biprime (2 × 3) which makes it the first member of the (2 × q) discrete biprime family, where q is a higher prime. Ħ is a pronic number and the only semiprime to be. It is also the largest of the four all-Harshad numbers (1, 2, 4, and 6). ![]() It is the smallest perfect number, which are numbers that are equal to their aliquot sum, or sum of their proper divisors. As such, 6 is the only number that is both the sum and product of three consecutive positive numbers. It is the second smallest composite number after four, equal to the sum and the product of its three proper divisors ( 1, 2 and 3). Six is the smallest positive integer which is neither a square number nor a prime number. It is a composite number and the smallest perfect number. 6 ( six) is the natural number following 5 and preceding 7. ![]()
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